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Postdoctoral Fellow - Genomics

San Diego, California
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Job ID 1738 Date posted 06/26/2019 Schedule Temporary Hours Full-Time Department Research & Clinical Management

This is a casual position with an anticipated end date of 9/30/2022.

JOB SUMMARY:

Contributes quality research outputs and conceptual support to projects. Works on problems of complex and diverse scope where analysis of situation or data requires an in-depth, independent evaluation of intangible variables or of various factors within defined parameters. Determines methods and procedures to carry out assignments and manages data and analysis for the project grant. Provides data management and analyses services. Conducts studies of related literature and research to support the design and implementation of projects and development of reports, ensuring conceptual relevance, comprehensiveness, and currency of information. Writes and publishes articles in peer-reviewed journals/digests that highlight findings from research and experimental activities ensuring consistency with the highest standards of academic publication.

This project is cutting edge in use of WGS to solve a complex familial cancer disease. It combines epidemiology, bioinformatics and wet-lab components. This position will be responsible for working in a multi-disciplinary group that seeks to identify novel (germline) genes that cause familial glioma, one of the most devastating cancers. Successful applicant will be expected to analyze several hundred whole genome sequences (WGS) from a diverse cohort, identify and rank interesting variants. These variants will then be functionally assessed in a wet lab setting. Identified genes will provide novel diagnostic and therapeutic targets for glioma and will be the first step in combating this terrible disease.

Applicant will be expected to independently conduct analysis (using R, perl/python/java or similar), write papers, and give presentations. Applicants will have extensive experience analyzing WGS/exome or similar datasets. Understanding or interest in cancer biology is a bonus. Applicant will also have access to a small cohort of WGS childhood CNS tumors which may further elucidate gliogenesis.

MINIMUM QUALIFICATIONS:

Doctorate Degree (non MD)

1 year of experience

Familiar with statistical analysis software (e.g., SPSS, SAS and or equivalent analytical software)

Strong scientific problem solving skills, ability to analyze and interpret experimental data, ability to communicate results in a concise manner both verbally and in writing, and have a solid track record of scientific achievement as documented by peer-reviewed scientific journal publications

Extensive training and at least 1 year experience in relevant research area

Proficient in internet use and able to conduct literature searches using search engines such as Psych Info and Pub Med

Background in administering diagnostic assessments in relevant research area

PREFERRED QUALIFICATIONS:

Familiar with linux, perl/python/ruby/java, R or similar

Familiar with samtools, bcftools, GATK, and other genomics tools

Familiar with genetics, genomics and cancer initiation

Strong scientific problem solving skills, ability to analyze and interpret experimental data, ability to communicate results in a concise manner both verbally and in writing, and have a solid track record of scientific achievement as documented by peer-reviewed scientific journal publications

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  • Research & Clinical Management, San Diego, California, United StatesRemove